<b>Bijsluiter</b>. De hyperlink naar het originele document werkt niet meer. Daarom laat Woogle de tekst zien die in dat document stond. Deze tekst kan vreemde foutieve woorden of zinnen bevatten en de opmaak kan verdwenen of veranderd zijn. Dit komt door het zwartlakken van vertrouwelijke informatie of doordat de tekst niet digitaal beschikbaar was en dus ingescand en vervolgens via OCR weer ingelezen is. Voor het originele document, neem contact op met de Woo-contactpersoon van het bestuursorgaan.<br><br>====================================================================== Pagina 1 ======================================================================

<pre>Ge zo n d hei d s raad
Health Council of the Netherlands
Thomas J. Lentz, PhD, M.P.H.
Branch Chief
Document Development Branch
Education and Information Division
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health (NIOSH)
1090 Tusculum Avenue
Cincinnati, OH 45226-199 8
USA
Subj ect            Comments on Adriamycin
Your reference       September 12, 2014, Letter + Comments on Adriamycin
Our reference        1-1 582/BvdV/cn/459-V71
Enclosure(s)       :2
Date               :Marchl8, 2015
Dear dr. Lentz,
Thank you and your colleagues dr. T. Connor and dr L. Rojanasakul for accepting the invitation to
comment on the draft report ‘Adriamycin’, which was published for public review in June 2014
by the Dutch Expert Committee on Occupational Safety (DECOS) of the Health Council of the
Netherlands.
The Committee highly appreciates the detailed comments presented by the NIOSH reviewers. The
Committee has incorporated quite a number of the recommended references in its final report.
Especially the studies regarding the occupational exposure of adriamycin were considered
important (Pieri et al., Kauppinen et al.) The Committee has shown some reluctance to elaborate
on studies that were too obviously concerned with therapeutic and clinical aspects of adriamycin
and made a selection from the recommended studies. Most of the studies on the genotoxic
mechanisms were included as reference, but the Committee did not choose for a detailed
discussion in the report.
In the Annex to this letter the responses by DECOS to all recommendations made by NIOSH are
specified.
P0. Box 16052                                                          Visiting Address
NL-2500 BB The Hague                                                   Rijnstraat 50
The Netherlands                                                        NL-2515 XP The Hague
Telephone +31 (70) 340 74 47                                           The Netherlands
E-mail: b.v.d.voetgr.nI                                                www. g r. fl1
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<pre>Gezond heidsraad
Health Council of the Netherlands
Subject              Comments on Adriamycin
Our reference        1-15 82/bvdV/cn1459-V7 1
Page               :2
Date                 March 18, 2015
Enciosed you find a copy of the final report on ‘Adriamycin’.
Yours sincerely,
                               .
                                 (_-t
           /_-z--7
         /
G.B. van der Voet, PhD, ERT
Scientific secretary
Enciosures:
         Detailed response by DECOS to NIOSH comments
         Final report on ‘Adriarnycin’
 P0. Box 16052                                                Visiting Address
 NL-2500 BB The Hague                                         Rijnstraat 50
The Netherlancfs                                              NL-2515 XP The Hague
Telephone +31 (70) 340 74 47                                  The Netherlands
 E-mail: b.v.d.voet@gr.nI                                     www. g r. ni
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