<b>Bijsluiter</b>. De hyperlink naar het originele document werkt niet meer. Daarom laat Woogle de tekst zien die in dat document stond. Deze tekst kan vreemde foutieve woorden of zinnen bevatten en de opmaak kan verdwenen of veranderd zijn. Dit komt door het zwartlakken van vertrouwelijke informatie of doordat de tekst niet digitaal beschikbaar was en dus ingescand en vervolgens via OCR weer ingelezen is. Voor het originele document, neem contact op met de Woo-contactpersoon van het bestuursorgaan.<br><br>====================================================================== Pagina 1 ======================================================================

<pre>Gezond hei dsraad
Health Council of the Netherlands
Dr TJ Lentz
Branch Chief
Document Development Branch, Education and Information Division
Centers for Disease Control and Prevention
National Institute for Occupational Safety and Health (NIOSH)
1090 Tusculum Avenue, MS C-32
Cincinnati, OH 45226-1998
USA
Subject              : Comment on public draft report Chroinium VI coinpounds
Your reference
Our reference          1-969171 IS V/jh/543-N 16
Enciosure(s)         : 1
Date                 :Mayl8,2016
Dear Dr. Lentz,
In 2015, the President of the Health Council of the Netherlands released the draft report Chroiniuin
(VI) coinpounds, prepared by the Committee on the Classification of Reproduction Toxic
Substances, for public review. This draft report is the first of this committee, that has been
prepared taking into account guidelines that are applied for proposals on classification and
labelling of chemicals under REACH’. As a consequence, the outline of the report differs from the
regular reports prepared by this Committee. It should be noted that these guidelines have no
consequences on the procedures applied by the Committee to reach its conclusions.
The Committee is pleased to note that the reviewers ofNlOSI-l confirm the completeness of the
data used, and support the conclusions of the Committee. The reviewers suggested several textual
changes, that have been adopted when finalizing the report. The reviewers have also suggested
some adaptations to the outline of the report (e.g. adding summaries, tables and a list of
abbreviations). As the outline has been defined by guidelines drafted by the Health Council, or
guidelines used under REACH, this will not be changed.
          The majority of the comments and literature suggestions on the content of de report
concern the section on read-across/toxicokinetics and mode of action. The Committee
acknowledges that this section can be described in more detail. The Committee however, aimed to
keep this section concise by using review document, and provide the basis of the group approach
without an indepth assessment of the mechanism of action. The Committee also notes that the
 literature suggested byNIOSH of chrornium cycling is primarily based on the carcinogenic
 1
   Registration, Evaluation and Authorisation of Chemicals; the regulation on chemicals of the EU.
 Postal address                                                                Visiting Address
 P0. Box 16052                                                                 Parnassusplein 5
 NL-2500 BB The Hague                                                          NL-251 1 XP The Hague
 Telephone +31 (70) 340 5508                                                   The Netheriands
 E-mail:sr.vink@gr.nl                                                          www. hea ithcou n cii. ni
</pre>

====================================================================== Einde pagina 1 =================================================================

<br><br>====================================================================== Pagina 2 ======================================================================

<pre>Gezond heidsraad
Health Council of the Netherlands
Subj ect             Comment on public draft report Chroinium VI compounds
Our reference        1-969171/S V/jh/543-N16
Page               :2
Date                 May 18, 2016
properties of chromium and does not provide specific information on the reproduction toxic
properties.
         In response to the suggestion to specify the dose of the control group in the units [mg/kg],
the Committee notes that the actual chromium intake of the control groups of animal experiments
is unknown. Therefore the Committee does not specify the dose in the control group.
         Finally, NIOSH suggested an environmental study on chroinium levels in drinking water
and the occurrence of late adverse pregnancy outcomes. The Committee has added this study as a
reference in the report.
On behalf of the Committee 1 thank you for taking the time to respond to the draft report, thus
enabling the Committee to issue a modified and improved final version. Your comment and this
reply will be published on the website of the Health Council.
The final report was published on May 1 8th, 2016. Enclosed     you will find a copy.
Yours sincerely,
 S.R. Vink, Ph.D.
 Scientific Secretary Committee on the
 Classification of Reproduction Toxic Substances
 Postal address                                                           Visiting Address
 P0. Box 16052                                                             Parnassusplein 5
 NL-2500 BB The Hague                                                      NL-2511 XP The Hague
 Telephone +31 (70) 340 5508                                              The Netherlands
 E-mail:sr.vink@gr.nl
</pre>

====================================================================== Einde pagina 2 =================================================================

<br><br>====================================================================== Pagina 3 ======================================================================

<pre>Gezond heidsraad
Health Council of the Netherlands
Mevrouw dr. J. Arts
Akzo Nobel
Onderwerp           Reactie op conceptadvies Chro,nium VI coinpounds
Uw kenmerk          e-mail d.d. 22januari 2016
Ons kenmerk         1-9 15558/S V/jh/543-O 16
Bij lagen
Datuiii             18mei2016
Geachte mevrouw Arts,
In november 201 5 heeft de Gezondheidsraad het conceptadvies Chromiu,n VI compounds van de
Commissie Classificatie reproductietoxische stoffen openbaar gemaakt. U hebt gebruikgemaakt
van de mogelijkheid om commentaar op het conceptadvies te leveren. Namens de commissie deel
ik u mede dat uw commentaar is verwerkt in liet advies. Aanvullend op uw commentaar wijst de
commissie op liet feit dat in het geval van een Categorie 1 B classificatie, de H-zin met een
hoofdletter wordt weergegeven (H3 60F).
De Gezondheidsraad dankt u hartelijk voor uw reactie. 1-let advies is op 18 mei gepubliceerd.
Bijgaand treft u een exemplaar aan.
Met vriendelijke groet,
dr. S.R. Vink
wetenschappelijk secretaris
 Bezoekadres                                                              Postadres
 Parnassusplein 5                                                         Postbus 16052
 2511 VX Den Haag                                                         2500 BB Den Haag
 E-mail:sr.vink@gr.nl                                                     www.gr.nI
 Telefoon (070) 340 5508
</pre>

====================================================================== Einde pagina 3 =================================================================

<br><br>